kir2ds3 is associated with protection against acute myeloid leukemia

KIR2DS3 is Associated with Protection against Acute Myeloid Leukemia

Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML;...

is heterochromatin polymorphism associated with chronic myeloid leukemia

introduction: heterochromatin consists of dna sequences that are not transcribed, and are repeated in short tandem at heterochromatic regions of chromosomes 1, 9, 16 as well as the distal part of long arm of chromosome y. slightly large tandem repeats at the centromeres of human chromosomes are also considered as heterochromatin regions. the main aim of the present study is to evaluate the hete...

NPM1 mutation is associated with leukemia cutis in acute myeloid leukemia with monocytic features.

Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion

Leukemia stem cells (LSCs) can resist available treatments that results in disease progression and/or relapse. To dissect the microRNA (miRNA) expression signature of relapse in acute myeloid leukemia (AML), miRNA array analysis was performed using enriched LSCs from paired bone marrow samples of an AML patient at different disease stages. We identified that miR-99a was significantly upregulate...

Unilateral Ptosis as Initial Manifestation of Acute Myeloid Leukemia

Abstract Background In Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of unilateral ptosis and unilateral eyelid swelling in AML has been reported during the present study. Case Report A 7-year-old girl was encountered with progressively increa...

Cancrum Oris-associated with Acute Myeloid Leukemia: A Forgotten Disease

Cancrum oris is an orofacial gangrene, which during its fulminating course causes, progressive and mutilating destruction of the infected tissues with a consortium of microorganisms. This condition is considered to represent the “face of poverty” because factors connected with poverty, such as chronic malnutrition, poor oral hygiene and sanitation, faecal contamination, and exposure to viral an...